Pretty URLs resulting in page load failure

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For the pretty URLs usage, this single page URL as an example fails resulting in page load failure:

[MyDomain]/system/users/groups/tables

The problem is found to be the folder structure and the number of subfolders, which is 3 in this example ie. system/users/groups. When the number of subfolders is reduced, the page is loaded correctly.

What makes this limitation? Can it be fixed in some way?

Janks