Problem with alignment when adding block to new layout

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I am populating a page with an array of thumbnails using Popup Pro. Suddenly, when I create a new one-row, one-column layout and insert the next block into it, the block is indented and the "Add to Main: Layout" area is now to the right of the block, rather than at the bottom. This is my fifth row of the array and the previous rows done this way worked fine. I tried it with the image block rather than Popup and get the same result, so I don't think it is a problem with Popup Pro. I also tried moving the problematic layout to the top of the page and still get the same problem. Any ideas what is causing this.

Here is a screen shot showing he problem:http://dl.dropbox.com/u/2240258/C5%20layout%20problem.JPG...