Content Sub-Templates

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How to do Sub-Templates for especially the main-content block best?

e.g. different columns

As a C5-Newbie at the moment I'm still using seperate copies of Page-Templates different in Main-Content area.

But there must be a better way that only affects the area and not the complete page,

maybe with custom-templates.

What would be best of practise?

Can you give an example to your Default-Theme?

eoi